Learned so much this past year, and wanted to take a moment to reflect on what this year has taught me. 2010 has been an absolute blur, so I felt a stream of consciousness-style response is most applicable.
Listen to your artist when something isn't working, you really share the same end goals. Read the reviews, sometimes they sting, but this can be the most objective feedback you get. Be true your intentions. You are doing this because you have something to say. Try to tackle something current, but make sure it's personal.
Remember how fortunate you are to be a part of the comics community. I have met many in the industry whose talent is matched by their generosity and intelligence. Read widely, beyond comics. How else is your work not going to be solely referential.
Try to engage the people who are supporting your work as opposed to waiting for an introduction. Ultimately the work should connect you with like-minded people. Talk to people who do not read comics. I've gotten some of my best ideas that way. Be willing to fail, it's the only way you have a chance at success. Remember to love doing the work, at the end of the day, it is the only thing in your control.